Scientific & Clinical Publications

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Nature Portfolio Aug 2025

Chronic Adaptive Deep Brain Stimulation for Parkinson's Disease: Clinical Outcomes & Programming Strategies

Journal: npj Parkinson's Disease (Nature Portfolio), 2025

DOI: 10.1038/s41531-025-01124-7

Summary:

This study presents the first real-world clinical outcomes of chronic adaptive deep brain stimulation (aDBS) in patients with Parkinson's disease. Eight adults received aDBS systems that automatically adjusted stimulation based on brain activity recorded from implanted electrodes.

The research demonstrates that:

Adaptive DBS significantly improves motor symptoms compared to conventional stimulation.
Daily symptom tracking through mobile ecological momentary assessments (EMA) provides a high-resolution view of fluctuations in movement, energy, well-being, and medication effects.
Home-based digital monitoring is crucial for evaluating therapy performance outside hospital settings.

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Chronic Adaptive Deep Brain Stimulation for Parkinson's Disease: Clinical Outcomes & Programming Strategies publication preview

Frontiers Jan 2024

Improving Naturalistic Neuroscience with Patient Engagement Strategies

Journal: Frontiers in Human Neuroscience, 2024

DOI: 10.3389/fnhum.2023.1325154

Summary:

This publication explores how engaging patients more deeply in study design—from sensor preferences to questionnaire structure—dramatically improves long-term compliance and data quality in real-world neuroscience.

The study identifies 3 major challenges in naturalistic research: